Supplementary Materials

This PDF file includes:

  • Fig. S1. 5-HT6R and GPRIN1 are colocalized at the soma plasma membrane of striatal and cortical neurons, but not in primary cilia.
  • Fig. S2. Analysis of cell lysates used for immunoprecipitation experiments.
  • Fig. S3. Effect of the phosphorylation of 5-HT6R Ser350 on its interaction with GPRIN1 and neurite morphology.
  • Fig. S4. Effect of GPRIN1 coexpression with the 5-HT6R on receptor cell surface expression in NG108-15 cells.
  • Fig. S5. GPRIN1 selectively affects the late stage of neurite growth in NG108-15 cells.
  • Fig. S6. The interaction between endogenous 5-HT6R and GPRIN1 promotes neurite extension through a cAMP-dependent mechanism in striatal neurons.

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