Supplementary Materials

This PDF file includes:

  • Fig. S1. ER Ca2+ release and SOCE in LS8 cells treated with various concentrations of NaF.
  • Fig. S2. Comparison of ER Ca2+ release by thapsigargin and tBHQ.
  • Fig. S3. ATP stimulation of fluoride-treated LS8 cells.
  • Fig. S4. Fluoride, but not chloride, affects Ca2+ homeostasis.
  • Fig. S5. Cell death analyses.
  • Fig. S6. Heat map of cell and ER stress genes in HEK-293 cells.
  • Fig. S7. Expression of the ER stress marker GRP78 in cells exposed to various NaF concentrations.
  • Fig. S8. Heat map of RP genes in HEK-293 cells.
  • Fig. S9. IP3 uncaging in primary secretory stage enamel cells.
  • Fig. S10. Transient fluoride application does not elicit changes in [Ca2+]cyt.
  • Fig. S11. Western blot of SERCA in LS8 cells treated with fluoride.
  • Fig. S12. Altering mitochondrial function by rotenone/oligomycin disrupts SOCE in LS8 cells.
  • Table S1. DEGs in fluoride-treated LS8 cells.
  • Table S2. DEGs in fluoride-treated HEK-293 cells.

[Download PDF]