Supplementary Materials

The PDF file includes:

  • Fig. S1. SERP1 expression influences AICD generation.
  • Fig. S2. SERP1 decreases the interaction of PS1 and NΔE.
  • Fig. S3. SERP1 regulates the amounts of γ-secretase subunits.
  • Fig. S4. SERP1 interacts with γ-secretase complex.
  • Fig. S5. The subcomplex of γ-secretase is dissociated by 1% Triton X-100.
  • Fig. S6. SERP1 colocalizes with APH1A.
  • Fig. S7. The C terminus of SERP1 is critical for γ-secretase activity.
  • Fig. S8. ER stress regulates the amount of SERP1 via IRE1 pathway.
  • Fig. S9. SERP1 and γ-secretase complex are up-regulated in diabetic mouse brains.
  • Fig. S10. Hyperglycemia increases the abundance of SERP1 and γ-secretase complex in SH-SY5Y cells.
  • Fig. S11. SERP1 abundance is increased in the parietal lobes of patients with Braak stage VI AD.
  • Fig. S12. Immunohistochemical detection of SERP1, SYP, or GFAP in the hippocampi of patients with AD.
  • Table S1. Top hits from the genome-wide functional screen.
  • Legend for data file S1

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Genome-wide functional screen data.