Supplementary Materials

This PDF file includes:

  • Fig. S1. LPS-induced TLR4 endocytosis promotes ARID5A, IL-6, and IL-12p40 production.
  • Fig. S2. ARID5A stabilizes IL6 mRNA, but not IL12B or TNF mRNA, through binding to its 3′UTR.
  • Fig. S3. TLR4 endocytosis–dependent IFN-β–JAK–STAT1-pTyr701 signaling is dispensable for ARID5A expression.
  • Fig. S4. Phosphorylation of STAT1 at Thr749 facilitates its binding to a noncanonical DNA motif in the ARID5A promoter region.
  • Fig. S5. A noncanonical TBK1-IKKβ heterodimer mediates the phosphorylation of STAT1 at Thr749 downstream of TLR4 endocytosis.
  • Table S1. List of primer sequences for RT-qPCR analysis, plasmid construction, and ChIP-qPCR assays.
  • Table S2. List of antibodies used for Western blotting and immunoprecipitations.

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