Supplementary Materials

This PDF file includes:

  • Fig. S1. MPC1 and MPC2 abundance after RNAi-mediated KD.
  • Fig. S2. Silencing MPC alters mitochondrial Ca2+ uptake in a MICU1-dependent manner.
  • Fig. S3. MPC1-deficient MEFs exhibit reduced MCU-mediated mitochondrial Ca2+ uptake and altered mitochondrial morphology.
  • Fig. S4. Pyruvate carrier mutations result in decreased matrix Ca2+ in a MICU1-dependent manner.
  • Fig. S5. Pharmacologic blockade of fatty acid and pyruvate flux by etomoxir and UK5099 enhances MICU1 mRNA abundance.

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