Supplementary Materials

This PDF file includes:

  • Fig. S1. Depolarization-induced I influx is a Ca2+-independent phenomenon.
  • Fig. S2. ER Ca2+ store depletion severely reduces Ca2+ transients and CaCC activation in response to capsaicin.
  • Fig. S3. Capsaicin applied in extracellular Ca2+-free conditions and acute TG-induced ER Ca2+ leak can induce a degree of CaCC activation.
  • Fig. S4. The cell-impermeable TRPV1 agonist K2 evokes cytosolic Ca2+ transients in the absence of extracellular Ca2+.
  • Fig. S5. Capsaicin induces PLC activation in DRG neurons.
  • Fig. S6. Controls for PLA.
  • Fig. S7. CD71 and IP3R1 are not found in close proximity as confirmed by PLA and STORM analysis.
  • Fig. S8. Decay rates of STORM fluorescent dye labels after repeated laser activation cycles.
  • Table S1. Mean percentages of STORM cluster distributions detected by DBSCAN.
  • Table S2. Mean cluster radius sizes of STORM-derived clusters detected by DBSCAN.
  • Table S3. Mean number of localizations per cluster from STORM-derived clusters detected by DBSCAN.

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