Supplementary Materials

This PDF file includes:

  • Fig. S1. Correlation between Hspa1 mRNA and creatinine in rat AKI study.
  • Fig. S2. Ponceau staining of rat kidney lysates.
  • Table S1. Effects of SAR247799 on the S1P receptor family.
  • Table S2. SAR247799 selectivity profile.
  • Table S3. S1P1 agonist and antagonist activities.
  • Table S4. S1P1 antagonist selectivity.
  • Table S5. IC50s of the S1P1 antagonist in blocking agonist-induced cAMP inhibition in HUVECs.
  • Table S6. Pharmacokinetic parameters of SAR247799 in pigs.
  • Table S7. Effect of vehicle, SAR247799, and l-arginine on hemodynamic parameters in the pig coronary occlusion model.
  • Table S8. Pharmacokinetic parameters of SAR247799 in rats.
  • Table S9. Plasma and tissue pharmacokinetic parameters of siponimod and SAR247799 in rats.
  • Table S10. Lymphocyte subset analysis in SAR247799-treated rats.

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