Supplementary Materials

This PDF file includes:

  • Fig. S1. Selectivity of IRAK4 and BTK inhibitors.
  • Fig. S2. Activity of IRAK4i-2 in whole blood using the gardiquimod stimulation assay.
  • Fig. S3. FcεR signaling in basophils.
  • Fig. S4. Inhibition of IFN-α2 production by inhibitors of IRAK4 or BTK.
  • Fig. S5. Ca2+ mobilization after stimulation of memory B cells with gardiquimod.
  • Fig. S6. Expression of IRG transcripts in whole blood.
  • Fig. S7. Expression of IRG transcripts in PBMCs.
  • Fig. S8. Plasma concentration of inhibitors in pristane-challenged mice.
  • Fig. S9. IRAK4 protein abundance in IRAK4-KD mice.
  • Fig. S10. Functional validation of IRAK4-KD mice.
  • Fig. S11. Ig subclasses in IRAK4-KD pristane-challenged mice.
  • Fig. S12. Evaluation of splenic plasma cells in IRAK4-KD mice.
  • Table S1. TaqMan probes used for Fluidigm expression analysis.

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