Supplementary Materials

This PDF file includes:

  • Fig. S1. Class I PI3K inhibition reduces MET-dependent cell migration but not anchorage-independent growth.
  • Fig. S2. Class I PI3K promotes MET-dependent cell migration through Rac1 activation.
  • Fig. S3. Oncogenic MET–induced anchorage-independent growth and tumor growth are mediated by mTORC1.
  • Fig. S4. Oncogenic MET promotes anchorage-independent growth through a Rac1-mTOR pathway.
  • Fig. S5. Rac1 promotes anchorage-independent growth in MET-mutant cells independently of its GTPase activity.
  • Fig. S6. Through its C-terminal RKR motif, Rac1 promotes the plasma membrane localization of mTOR and the anchorage-independent growth of MET-mutant cells.
  • Table S1. RNAi oligonucleotides and the Rac1-T17N-AAA plasmid.

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