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  • Fig. S1. Mitochondrial parameters and simultaneous knockdown of types 1 and 3 InsP3R induces cell death in OXPHOS-defective 143BΔcytb cells.
  • Fig. S2. Pseudohypoxic RCC4 cells rely on constitutive InsP3R-mediated Ca2+ signals.
  • Fig. S3. Inhibition of constitutive InsP3R-mediated Ca2+ transfer to the mitochondria substantially changes the metabolomic profile of 143BΔcytb cell lines.
  • Fig. S4. OXPHOS-defective cells rely on constitutive InsP3R-mediated Ca2+ signals.
  • Fig. S5. Inhibition of constitutive InsP3R-mediated Ca2+ release reduces αKGDH activity and activates SIRT1 and AMPK.
  • Fig. S6. SIRT1 is necessary for the autophagy induced by inhibition of Ca2+ transfer to mitochondria.

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