Supplementary Materials

The PDF file includes:

  • Fig. S1. Body weight, body composition, and temperature at each tissue collection time point.
  • Fig. S2. Classification of metabolites based on the impact of diet or/and temperature.
  • Fig. S3. Effect of thermoneutrality on intertissue correlations.
  • Fig. S4. Temperature dictates fuel use and energy expenditure during CR.
  • Fig. S5. Cognitive prioritization of metabolites.
  • Fig. S6. The citrulline-NO cycle and polyamine metabolism are affected by housing temperature.
  • Legends for data files S1 to S11

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Plasma metabolite area and SD at both temperatures with statistics.
  • Data file S2 (Microsoft Excel format). Hypothalamus metabolite area and SD at both temperatures with statistics.
  • Data file S3 (Microsoft Excel format). Pathway enrichment analysis for plasma and hypothalamus metabolites.
  • Data file S4 (Microsoft Excel format). Intra- and intertissue correlations.
  • Data file S5 (Microsoft Excel format). Glucogenic amino acids in plasma.
  • Data file S6 (Microsoft Excel format). Cognitive prioritization of metabolites.
  • Data file S7 (Microsoft Excel format). Core body temperature of mice during CR with statistics.
  • Data file S8 (Microsoft Excel format). Locomotor activity of mice during CR with statistics.
  • Data file S9 (Microsoft Excel format). RER of mice during CR with statistics.
  • Data file S10 (Microsoft Excel format). Energy expenditure of mice during CR with statistics.
  • Data file S11 (Microsoft Excel format). Body weight of mice during CR with statistics.