Supplementary Materials

The PDF file includes:

  • Fig. S1. Erlotinib drug GRADE in TNBC compared to PC9 cells.
  • Fig. S2. ERK activation upon erlotinib treatment in TNBC cells.
  • Fig. S3. RTK expression changes upon erlotinib exposure.
  • Fig. S4. Overview of genome-wide screen and analysis.
  • Fig. S5. Varied levels of ELP complex essentiality in TNBC cells.
  • Fig. S6. Validation of ELP knockdown.
  • Fig. S7. Correlations between erlotinib sensitivity and EGFR, MCL1, and ELP expression.
  • Fig. S8. ELP complex facilitates expression of MCL1 upon erlotinib exposure.
  • Fig. S9. Expression of apoptotic regulatory proteins upon erlotinib exposure.
  • Fig. S10. Mcl-1 inhibition synergistically enhances sensitivity to erlotinib in a panel of TNBC cells.
  • Table S1. Sequences for siRNAs targeting ELP3 to ELP6.
  • Legends for data files S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Raw counts from genome-wide screen.
  • Data file S2 (Microsoft Excel format). Gene-level fold change from genome-wide screen.