Supplementary Materials
This PDF file includes:
- Text S1. Extended discussion on the potential of NRPs in SARS-CoV-2 cell entry.
- Fig. S1. The structural feasibility of simultaneous integrin and ACE2 binding by SARS-CoV-2 spike protein trimers.
- Fig. S2. Structural indication of a functional spike protein RBD:integrin αvβ6 interaction.
- Fig. S3. Alignment of human ACE2 transmembrane helix and C-terminal intracellular tail with homologous sequences of representative vertebrate collectrins from UniProt reference proteomes.
- Fig. S4. Alignment of homologous sequences of integrin β3 transmembrane helices and intracellular tails.
- Fig. S5. Alignment of homologous sequences of integrin β1 transmembrane helices and intracellular tails.
- Fig. S6. Alignment of homologous sequences of integrin β6 transmembrane helices and intracellular tails.
- Fig. S7. PTMs in β-integrin tails.
- Fig. S8. Transmembrane and intracellular regions of NRP1 and NRP2.
- Table S1. SH2 domain specificity for the candidate ACE2 tail SH2 motif.
- References (229–235)
