Supplementary Materials

This PDF file includes:

  • Text S1. Extended discussion on the potential of NRPs in SARS-CoV-2 cell entry.
  • Fig. S1. The structural feasibility of simultaneous integrin and ACE2 binding by SARS-CoV-2 spike protein trimers.
  • Fig. S2. Structural indication of a functional spike protein RBD:integrin αvβ6 interaction.
  • Fig. S3. Alignment of human ACE2 transmembrane helix and C-terminal intracellular tail with homologous sequences of representative vertebrate collectrins from UniProt reference proteomes.
  • Fig. S4. Alignment of homologous sequences of integrin β3 transmembrane helices and intracellular tails.
  • Fig. S5. Alignment of homologous sequences of integrin β1 transmembrane helices and intracellular tails.
  • Fig. S6. Alignment of homologous sequences of integrin β6 transmembrane helices and intracellular tails.
  • Fig. S7. PTMs in β-integrin tails.
  • Fig. S8. Transmembrane and intracellular regions of NRP1 and NRP2.
  • Table S1. SH2 domain specificity for the candidate ACE2 tail SH2 motif.
  • References (229235)

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