Supplementary Materials
The PDF file includes:
- Fig. S1. ISRIB does not attenuate the increase in hippocampal Atf4 mRNA or the reductions in BDNF, PSD-95, and synaptophysin abundance induced by AβOs in mice.
- Fig. S2. ISRIB does not alter locomotor activities.
- Fig. S3. ISRIB restores GADD34 levels in the hippocampus of APPswe/PS1ΔE9 mice.
- Fig. S4. Locomotor and exploratory activities and body weight of APPswe/PS1ΔE9 are not altered by ISRIB treatment.
- Fig. S5. Gliosis in APPswe/PS1ΔE9 hippocampi (dentate gyrus/stratum lacunosum moleculare) is unaffected by ISRIB treatment.
- Fig. S6. Full Western blots obtained in this study.
- Table S1. Demographics of brain tissue donors.
- Legend for data file S1
Other Supplementary Material for this manuscript includes the following:
- Data file S1 (Microsoft Excel format). Numerical analyses.