Supplementary Materials

The PDF file includes:

  • Fig. S1. ISRIB does not attenuate the increase in hippocampal Atf4 mRNA or the reductions in BDNF, PSD-95, and synaptophysin abundance induced by AβOs in mice.
  • Fig. S2. ISRIB does not alter locomotor activities.
  • Fig. S3. ISRIB restores GADD34 levels in the hippocampus of APPswe/PS1ΔE9 mice.
  • Fig. S4. Locomotor and exploratory activities and body weight of APPswe/PS1ΔE9 are not altered by ISRIB treatment.
  • Fig. S5. Gliosis in APPswe/PS1ΔE9 hippocampi (dentate gyrus/stratum lacunosum moleculare) is unaffected by ISRIB treatment.
  • Fig. S6. Full Western blots obtained in this study.
  • Table S1. Demographics of brain tissue donors.
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following: