Supplementary Materials

The PDF file includes:

• Fig. S1. Blockade of the ligand-independent activity of GHS-R1a decreases the synapse density in mature primary cultured hippocampal neurons.
• Fig. S2. Blockade of the ligand-independent activity of GHS-R1a increases the cell surface diffusion of GluA2-AMPARs.
• Fig. S3. Administration of an inverse agonist of GHS-R1a does not impair overall movement.
• Legends for movies S1 and S2

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mp4 format). Application of the GHS-R1a agonist MK-0677 induces the translocation of PLCδPH-GFP from the plasma membrane into the cytosol.
• Movie S2 (.mp4 format). Application of the GHS-R1a inverse agonist SP-A increases the plasma membrane levels of PLCδPH-GFP.