Supplementary Materials
The PDF file includes:
- Materials and Methods
- Fig. S1. Cell-cycle dependence of the transcriptional response.
- Fig. S2. Quantifying persistence in response to a 90-min pulse of stimulus.
- Fig. S3. Simple delay model.
- Fig. S4. Score distribution for varied Hill coefficients.
- Fig. S5. MAPK activation dynamics.
- Fig. S6. PSTE5-STE12 and WT strains have similar basal Ste12 abundance.
- Fig. S7. Degradation of Ste12 in the Ste12-Dig complex prevents adaptation.
- Fig. S8. The model captures responses to dynamic stimulation.
- Fig. S9. Parameter distributions.
- Fig. S10. Effect of parameter distributions on the predicted response for the dig1Δdig2Δ strain.
- Fig. S11. Persistence of different pathway perturbations in response to a 90-min pulse of stimulus.
- Table S1. Plasmids used in this study.
- Table S2. Oligonucleotide sequences.
- Table S3. Strains used in this study.
- Table S4. Parameter ranges for the evolutionary algorithm.
- References (61–81)
