Supplementary Materials

The PDF file includes:

  • Fig. S1. Characterization of PKC defect in TORC2-deficient cells.
  • Fig. S2. Determinants for mTORC2 association with PKC.
  • Fig. S3. Active-site tether region of PKC C-tail confers mTORC2 dependence.
  • Fig. S4. Molecular modeling of the Sin1:PKC interaction.
  • Fig. S5. MS analysis of mTORC2 kinase assays.
  • Fig. S6. TIM phosphorylation and evolutionary conservation.
  • Fig. S7. Conservation of the TIM with TOR pathway components.
  • Fig. S8. PKN dependence on TIM and turn motif sites.
  • Fig. S9. mTORC2 recruits PDK1 to the PKC C-tail.
  • Fig. S10. TIM mutations affect kinase conformations.
  • Fig. S11. Regulatory domains attenuate PKC dimerization.
  • References (123130)

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