Supplementary Materials

The PDF file includes:

  • Fig. S1. CLIC1 and CLIC4 promote EC survival and localize to the plasma membrane in response to S1P.
  • Fig. S2. CLICs regulate S1P-driven barrier integrity and VE-cadherin junction formation.
  • Fig. S3. Loss of CLICs did not alter basal Rac1 activity or EGF-induced Ras activation.
  • Fig. S4. Ectopic expression of CLIC1 and CLIC4 rescues EC viability and S1P-mediated migration.

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