PT  - JOURNAL ARTICLE
ED  - , 
TI  - Rac2 in Th1 Cells
AID  - 10.1126/stke.2000.38.tw7
DP  - 2000 Jun 27
TA  - Science's STKE
PG  - tw7--tw7
VI  - 2000
IP  - 38
4099  - http://stke.sciencemag.org/content/2000/38/tw7.short
4100  - http://stke.sciencemag.org/content/2000/38/tw7.full
SO  - Sci. STKE2000 Jun 27; 2000
AB  - Immune responses can be mediated by cells (cell-mediated immunity) or through circulating factors like antibodies (humoral immunity), depending on whether naive T cells differentiate into T helper 1 (Th1) or T helper 2 (Th2) cells. Li et al. report that the small guanosine triphosphatase Rac2 increased the expression of interferon γ (IFNγ), a cytokine that promotes T cell differentiation, and that it appeared to signal through the mitogen-activated protein kinase p38 and the transcription factor NF-κB. Li, B., Yu, H. Zheng, W.-P., Voll, R., Na, S., Roberts, A.W., Williams, D.A., Davis, R.J., Ghosh, S., and Flavell, R.A. (2000) Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science 288: 2219-2222. [Abstract] [Full Text]