RT Journal Article
SR Electronic
T1 Odorants Modulate CREB in Olfactory Neurons
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw3
OP tw3
DO 10.1126/stke.1999.12.tw3
VO 1999
IS 12
YR 1999
UL http://stke.sciencemag.org/content/1999/12/tw3.abstract
AB Stimulation of odorant receptors in olfactory neurons can result in an immediate and a delayed increase in intracellular cAMP. While the immediate cAMP response includes an influx of sodium and calcium and the generation of an action potential, the later cAMP signal is thought to produce long-term changes in neuron function, possibly through modulation of gene expression. Moon et al. report that phosphorylation of a transcription factor called the cAMP-responsive binding protein (CREB) occurred in the olfactory epithelium of mice when they were exposed to various odorants. Phosphorylation occurred at a specific serine residue, a modification required for CREB activation and DNA binding. Exposure of olfactory receptor cells to cGMP also stimulated phosphorylation of CREB. The authors previously proposed that the cGMP activates protein kinase G, which in turn activates adenyl cyclase and causes the observed delayed increase in intracellular cAMP. This report may extend this cGMP-cAMP signaling pathway to CREB and the transcription of specific genes. Moon, C., Sung, Y.-K., Reddy, R., and Ronnett, G.V. (1999) Odorants induce the phosphorylation of the cAMP response element binding protein in olfactory receptor neurons. Proc. Natl. Acad. Sci. U.S.A. 96: 14605-14610. [Abstract] [Full Text]