PT  - JOURNAL ARTICLE
AU  - Lee, Hon Cheung
TI  - Multiple Calcium Stores: Separate but Interacting
AID  - 10.1126/stke.2000.40.pe1
DP  - 2000 Jul 11
TA  - Science's STKE
PG  - pe1--pe1
VI  - 2000
IP  - 40
4099  - http://stke.sciencemag.org/content/2000/40/pe1.short
4100  - http://stke.sciencemag.org/content/2000/40/pe1.full
SO  - Sci. STKE2000 Jul 11; 2000
AB  - Multiple mechanisms exist for increasing the concentration of intracellular calcium. This Perspective by Lee is one in a series on intracellular calcium release mechanisms and focuses on the calcium store operated by nicotinic acid adenine dinucleotide phosphate (NAADP). The characterization of the NAADP-operated calcium store as separate from the inositol trisphosphate (IP3)-operated and cyclic ADP-ribose (cADPR)-operated calcium stores is discussed. Lee also addresses the role of NAADP in regulating intracellular calcium fluctuations during fertilization and hormonal activation of pancreatic acinar cells.