PT  - JOURNAL ARTICLE
ED  - , 
TI  - Mighty Deadly MyD88
AID  - 10.1126/stke.2000.40.tw3
DP  - 2000 Jul 11
TA  - Science's STKE
PG  - tw3--tw3
VI  - 2000
IP  - 40
4099  - http://stke.sciencemag.org/content/2000/40/tw3.short
4100  - http://stke.sciencemag.org/content/2000/40/tw3.full
SO  - Sci. STKE2000 Jul 11; 2000
AB  - Toll receptors are activated by bacterially produced pathogen-associated molecular pattern (PAMPs). Bacterial lipoproteins (BLPs) are PAMPs that activate the Toll-like receptor 2 (TLR2) through recruitment of the adaptor molecule MyD88. Transfection of a variety of dominant negative mutants allowed Aliprantis et al. to show that MyD88 is a common mediator for both the cell survival signal mediated by NF-κB activation and the apoptotic signal mediated through Fas-associated death domain protein (FADD). FADD activation is dependent on the death domain (DD) of MyD88, and the two proteins could be coimmunoprecipitated from transfected cells, confirming a physical interaction between them. Apoptosis was inhibited by mutant forms of caspase 8, FADD, or MyD88, confirming an apoptosis pathway from TLR2 to MyD88 to FADD to caspase 8. Aliprantis, A.O., Yang, R.-B., Weiss, D.S., Godowski, P., and Zychlinsky, A. (2000) The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 19: 3325-3336. [Abstract] [Full Text]