PT  - JOURNAL ARTICLE
AU  - DeFranco, Donald B.
AU  - Csermely, Peter
TI  - Steroid Receptor and Molecular Chaperone Encounters in the Nucleus
AID  - 10.1126/stke.2000.42.pe1
DP  - 2000 Jul 25
TA  - Science's STKE
PG  - pe1--pe1
VI  - 2000
IP  - 42
4099  - http://stke.sciencemag.org/content/2000/42/pe1.short
4100  - http://stke.sciencemag.org/content/2000/42/pe1.full
SO  - Sci. STKE2000 Jul 25; 2000
AB  - Steroid hormone receptors interact with several different molecular chaperones. DeFranco and Csermely discuss how the molecular chaperones p23 and Hsp90 may serve to regulate the activity of the ligand-bound steroid receptors within the nucleus. The authors hypothesize that these chaperone proteins may have a proactive role in promoting recycling of receptors once they have interacted with chromatin and in allowing rebinding of ligand once the receptors have been recycled.