PT  - JOURNAL ARTICLE
ED  - , 
TI  - Refilling the Stores
AID  - 10.1126/stke.2000.42.tw7
DP  - 2000 Jul 25
TA  - Science's STKE
PG  - tw7--tw7
VI  - 2000
IP  - 42
4099  - http://stke.sciencemag.org/content/2000/42/tw7.short
4100  - http://stke.sciencemag.org/content/2000/42/tw7.full
SO  - Sci. STKE2000 Jul 25; 2000
AB  - G proteins (proteins that bind GTP, guanosine 5'-triphosphate) are involved in vesicle endocytosis and exocytosis in a variety of non-neuronal cells. Takahashi et al. analyzed the contribution of G proteins to fast synaptic neurotransmitter release. They introduced several nonhydrolyzable GTP analogs into the giant nerve terminals at the calyx of Held. The rate of recovery from synaptic depression was significantly influenced by these analogs. G proteins help refill synaptic vesicles after massive exocytosis. Takahashi,T., Hori, T., Kajikawa, Y., and Tsujimoto, T. (2000) The role of GTP-binding protein activity in fast central synaptic transmission. Science 289: 460-463. [Abstract] [Full Text]