RT Journal Article
SR Electronic
T1 Neuronal Signal Transduction Pathways: Wasteland or the Promised Land?
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe1
OP pe1
DO 10.1126/stke.2000.45.pe1
VO 2000
IS 45
A1 Roth, Bryan L.
YR 2000
UL http://stke.sciencemag.org/content/2000/45/pe1.abstract
AB Review and commentary on Cerebral Signal Transduction: From First to Fourth Messengers, edited by Maarten E. A. Reith. The Humana Press, Totowa, NJ, 2000. 440 pp. $125.00 Proteins used in signal transduction pathways are commonly found in different cell types and organs. However, specific proteins whose expression is highly restricted are also utilized for allowing discrete responsiveness to signals that are otherwise ignored by other cells. How the brain uses common and specific signal proteins for communication within and beyond the cerebrum has been an area of intense study. A new book concentrates on the signaling that occurs in the brain under normal and pathological conditions--memory, apoptosis, neurodegeneration, depression, and drug dependence--and is filled with chapters written by experts in neurobiology and neurophysiology. Bryan Roth reviews the book and discusses in detail several chapters that may lead to promising future research.