PT  - JOURNAL ARTICLE
AU  - Edidin, Michael
TI  - Membrane Cholesterol, Protein Phosphorylation, and Lipid Rafts
AID  - 10.1126/stke.2001.67.pe1
DP  - 2001 Jan 30
TA  - Science's STKE
PG  - pe1--pe1
VI  - 2001
IP  - 67
4099  - http://stke.sciencemag.org/content/2001/67/pe1.short
4100  - http://stke.sciencemag.org/content/2001/67/pe1.full
SO  - Sci. STKE2001 Jan 30; 2001
AB  - The functions of cholesterol and membrane microdomains in transmembrane signaling remain controversial. Edidin discusses the questions surrounding lipid rafts, membrane microdomains that have been biochemically defined but are difficult to visualize in vivo. He also discusses whether experiments showing correlation of changes in plasma membrane cholesterol with differentiation and the formation of adherens junctions in endothelial cells are consistent with a model in which lipid rafts influence the regulation of these processes.