RT Journal Article
SR Electronic
T1 Membrane Cholesterol, Protein Phosphorylation, and Lipid Rafts
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe1
OP pe1
DO 10.1126/stke.2001.67.pe1
VO 2001
IS 67
A1 Edidin, Michael
YR 2001
UL http://stke.sciencemag.org/content/2001/67/pe1.abstract
AB The functions of cholesterol and membrane microdomains in transmembrane signaling remain controversial. Edidin discusses the questions surrounding lipid rafts, membrane microdomains that have been biochemically defined but are difficult to visualize in vivo. He also discusses whether experiments showing correlation of changes in plasma membrane cholesterol with differentiation and the formation of adherens junctions in endothelial cells are consistent with a model in which lipid rafts influence the regulation of these processes.