RT Journal Article SR Electronic T1 Reviewing the Paths to Aging JF Science's STKE JO Sci. STKE FD American Association for the Advancement of Science SP tw8 OP tw8 DO 10.1126/stke.2000.58.tw8 VO 2000 IS 58 YR 2000 UL http://stke.sciencemag.org/content/2000/58/tw8.abstract AB Two reviews discuss signal pathways that influence the aging process. Finkel and Holbrook cover how oxidants contribute to the aging process, the cellular signaling pathways that lead to altered cellular redox state, and the pathways activated in response to oxidative stress. Guarente and Kenyon describe mechanisms of aging learned from studies in the genetically tractable model systems budding yeast and the nematode, Caenorhabditis elegans. In yeast, the pathway linking metabolic rate to aging appears to converge at a protein involved in gene silencing. Major pathways identified in C. elegans include the regulation of life-span by hormone signaling and sensory stimulation. Finkel, T., and Holbrook, N.J. (2000) Oxidants, oxidative stress, and the biology of ageing. Nature 408: 9-17. [Online Journal] Guarente, L., and Kenyon, C. (2000) Genetic pathways that regulate ageing in model organisms. Nature 408: 25-32. [Online Journal]