PT - JOURNAL ARTICLE ED - , TI - Muscle Cells on the Move AID - 10.1126/stke.2001.80.tw5 DP - 2001 May 01 TA - Science's STKE PG - tw5--tw5 VI - 2001 IP - 80 4099 - http://stke.sciencemag.org/content/2001/80/tw5.short 4100 - http://stke.sciencemag.org/content/2001/80/tw5.full SO - Sci. STKE2001 May 01; 2001 AB - The ligand Slit and its corresponding receptor Roundabout (Robo) are notorious for providing guidance signals to axons finding their initial pathways during early Drosophila development. Kramer et al. now show that the Slit and Robo combination is even more versatile than previously thought. Muscle cells also migrate during the early stages of muscle organization under the direction of the Slit and Robo team. The response switches from repulsive to attractive; initially repelled by Slit at the midline, muscle cells are later attracted by Slit at specific attachment sites. S. G. Kramer, T. Kidd, J. H. Simpson, C. S. Goodman, Switching repulsion to attraction: Changing responses to Slit during transition in mesoderm migration. Science 292, 737-740 (2001). [Abstract] [Full Text]