PT  - JOURNAL ARTICLE
ED  - , 
TI  - Muscle Cells on the Move
AID  - 10.1126/stke.2001.80.tw5
DP  - 2001 May 01
TA  - Science's STKE
PG  - tw5--tw5
VI  - 2001
IP  - 80
4099  - http://stke.sciencemag.org/content/2001/80/tw5.short
4100  - http://stke.sciencemag.org/content/2001/80/tw5.full
SO  - Sci. STKE2001 May 01; 2001
AB  - The ligand Slit and its corresponding receptor Roundabout (Robo) are notorious for providing guidance signals to axons finding their initial pathways during early Drosophila development. Kramer et al. now show that the Slit and Robo combination is even more versatile than previously thought. Muscle cells also migrate during the early stages of muscle organization under the direction of the Slit and Robo team. The response switches from repulsive to attractive; initially repelled by Slit at the midline, muscle cells are later attracted by Slit at specific attachment sites. S. G. Kramer, T. Kidd, J. H. Simpson, C. S. Goodman, Switching repulsion to attraction: Changing responses to Slit during transition in mesoderm migration. Science 292, 737-740 (2001). [Abstract] [Full Text]