RT Journal Article SR Electronic T1 New Functions for DNA Binding Domains JF Science's STKE JO Sci. STKE FD American Association for the Advancement of Science SP pe1 OP pe1 DO 10.1126/stke.2001.81.pe1 VO 2001 IS 81 A1 Rao, Anjana YR 2001 UL http://stke.sciencemag.org/content/2001/81/pe1.abstract AB How the same transcription factor can be both an activator and a repressor of transcription is a biological mystery. Rao describes work that shows that the structure of the transcription factor may actually change depending on the DNA sequence bound by the factor. This change in structure may influence the binding of activators or repressors of transcription, thus allowing a single transcription factor to have two different activities.