RT Journal Article
SR Electronic
T1 New Functions for DNA Binding Domains
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe1
OP pe1
DO 10.1126/stke.2001.81.pe1
VO 2001
IS 81
A1 Rao, Anjana
YR 2001
UL http://stke.sciencemag.org/content/2001/81/pe1.abstract
AB How the same transcription factor can be both an activator and a repressor of transcription is a biological mystery. Rao describes work that shows that the structure of the transcription factor may actually change depending on the DNA sequence bound by the factor. This change in structure may influence the binding of activators or repressors of transcription, thus allowing a single transcription factor to have two different activities.