PT  - JOURNAL ARTICLE
AU  - Ashman, Keith
AU  - Moran, Michael F.
AU  - Sicheri, Frank 
AU  - Pawson, Tony
AU  - Tyers, Mike
TI  - Cell Signalling - The Proteomics of It All
AID  - 10.1126/stke.2001.103.pe33
DP  - 2001 Oct 09
TA  - Science's STKE
PG  - pe33--pe33
VI  - 2001
IP  - 103
4099  - http://stke.sciencemag.org/content/2001/103/pe33.short
4100  - http://stke.sciencemag.org/content/2001/103/pe33.full
SO  - Sci. STKE2001 Oct 09; 2001
AB  - A challenge for biomedical scientists today is to arrive at an understanding of cellular behavior on a global scale. The advent of DNA microarrays has greatly facilitated discovery of gene expression profiles associated with different cellular states. The problem of understanding cellular signaling at the level of the interacting proteins is in some ways more challenging. Ashman et al. discuss the current methods available for studying protein interactions on a global scale, as well as directions for the future. Technical hurdles exist at many stages, from the isolation of protein complexes, to the determination of their composition, to the software and databases needed to analyze the results of large-scale, high-throughput datasets. Ashman et al. suggest that, with advances in technology and cooperation among academia and industry, a global protein interaction map that underlies cellular behavior will emerge as an essential resource for basic and applied research.