RT Journal Article
SR Electronic
T1 TGF-β Flips the Myc Switch
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe1
OP pe1
DO 10.1126/stke.2001.88.pe1
VO 2001
IS 88
A1 Orian, Amir
A1 Eisenman, Robert N.
YR 2001
UL http://stke.sciencemag.org/content/2001/88/pe1.abstract
AB Although transforming growth factor-β (TGF-β) can affect cell cycle arrest, not much molecular detail is known about how TGF-β-dependent arrest is mediated. Two recent papers shed some light on how this is accomplished. Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15INK4b, and how TGF-β is able to unblock Myc-dependent repression of Miz-1.