RT Journal Article
SR Electronic
T1 Redox Control of Growth
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw4
OP tw4
DO 10.1126/stke.2001.88.tw4
VO 2001
IS 88
YR 2001
UL http://stke.sciencemag.org/content/2001/88/tw4.abstract
AB Prokaryotes sense change in environmental oxygen through a two-component signal transduction system and adjust their metabolism accordingly. Surprisingly, oxygen is not the molecular signal that regulates this process, which involves a membrane-associated sensor kinase and a response regulator that modulates gene expression. Georgellis et al. have determined that the redox state of membrane-bound quinones regulates the ArcB sensor kinase of the bacterium Escherichia coli; quinones are carriers in electron transport chains that are linked to metabolic reactions. D. Georgellis, O. Kwon, E. C. C. Lin, Quinones as the redox signal for the Arc two-component system of bacteria. Science 292, 2314-2316 (2001). [Abstract] [Full Text]