RT Journal Article
SR Electronic
T1 Unzipping Ion Channels
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe1
OP pe1
DO 10.1126/stke.2001.98.pe1
VO 2001
IS 98
A1 MacFarlane, Stacey Nee
A1 Levitan, Irwin B.
YR 2001
UL http://stke.sciencemag.org/content/2001/98/pe1.abstract
AB The functions of ion channels can be regulated by their phosphorylation state. Protein kinases and protein phosphatases tightly control the activity of channels, thereby regulating the flow of ions across cell membranes. Channel proteins and kinases or phosphatases can associate directly or through intermediate adaptor proteins. An interaction domain termed the leucine zipper (LZ), once thought to be unique to some families of transcription factors, has been identified in channel proteins and their cognate binding proteins. MacFarlane and Levitan discuss what roles LZ-containing proteins might have in controlling channel function.