RT Journal Article
SR Electronic
T1 Microtubule-Actin Cross-talk at Focal Adhesions
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe31
OP pe31
DO 10.1126/stke.2002.139.pe31
VO 2002
IS 139
A1 Palazzo, Alexander F.
A1 Gundersen, Gregg G.
YR 2002
UL http://stke.sciencemag.org/content/2002/139/pe31.abstract
AB Focal adhesions are dynamic structures in which traction forces are exerted against the substratum during cell migration and are sites for the organization of signaling complexes. Palazzo and Gundersen discuss how focal adhesions may also be the site of cross-talk between the actin-based and microtubule-based cytoskeletons. Microtubules appear to deliver factors that can regulate the formation and dissolution of focal adhesions, whereas focal adhesions contribute to microtubule localization and stability.