PT  - JOURNAL ARTICLE
AU  - Louis, Matthieu
AU  - Becskei, Attila
TI  - Binary and Graded Responses in Gene Networks
AID  - 10.1126/stke.2002.143.pe33
DP  - 2002 Jul 30
TA  - Science's STKE
PG  - pe33--pe33
VI  - 2002
IP  - 143
4099  - http://stke.sciencemag.org/content/2002/143/pe33.short
4100  - http://stke.sciencemag.org/content/2002/143/pe33.full
SO  - Sci. STKE2002 Jul 30; 2002
AB  - Although gene expression can be regulated in a graded or a binary fashion, the majority of eukaryotic genes are either fully activated or not expressed at all in individual cells. This binary response might be an inherent property of many eukaryotic promoters. Analysis of transcription under the control of yeast GAL1 promoter suggests, however, that graded and binary modes of transcription are not mutually exclusive, but that both can occur at the same promoter when the activity of different signaling pathways is varied. In view of that, it can be expected that forthcoming experimental studies on the combinatorial effects of signaling and transcriptional mechanisms will reveal new strategies for generating graded or binary responses.