PT  - JOURNAL ARTICLE
AU  - Bismuth, Georges
AU  - Boumsell, Laurence
TI  - Controlling the Immune System Through Semaphorins
AID  - 10.1126/stke.1282002re4
DP  - 2002 Apr 16
TA  - Science's STKE
PG  - re4--re4
VI  - 2002
IP  - 128
4099  - http://stke.sciencemag.org/content/2002/128/re4.short
4100  - http://stke.sciencemag.org/content/2002/128/re4.full
SO  - Sci. STKE2002 Apr 16; 2002
AB  - Semaphorins provide crucial attractive and repulsive cues involved in axon guidance. Several semaphorins have also been detected in cells of the immune system. Their influence on cell motility has been reported and is reminiscent of the biological function attributed to nervous system semaphorins. Receptors of the plexin and neuropilin family of proteins, also expressed by some immune cells, may be involved in semaphorin signaling in the immune system. However, semaphorins also affect the functioning of the immune system through receptors regulating lymphocyte activation. An important challenge in the future will be to determine whether, as in the nervous system, semaphorins help immune cells to establish connections with their appropriate targets.