RT Journal Article SR Electronic T1 Creating Asymmetric Cell Divisions by Skewing Endocytosis JF Science's STKE JO Sci. STKE FD American Association for the Advancement of Science SP pe52 OP pe52 DO 10.1126/stke.2002.162.pe52 VO 2002 IS 162 A1 Shen, Qin A1 Temple, Sally YR 2002 UL http://stke.sciencemag.org/content/2002/162/pe52.abstract AB How can one cell divide to form two cells, which are genetically identical to the mother cell, with different cell fates? That is the question discussed by Shen and Temple. Specifically, they address how Notch signaling is attenuated in one daughter cell through the asymmetric inheritance of the protein Numb, which may be responsible for mediating the endocytosis of the receptor Notch in the Numb-enriched cell.