RT Journal Article
SR Electronic
T1 Creating Asymmetric Cell Divisions by Skewing Endocytosis
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe52
OP pe52
DO 10.1126/stke.2002.162.pe52
VO 2002
IS 162
A1 Shen, Qin
A1 Temple, Sally
YR 2002
UL http://stke.sciencemag.org/content/2002/162/pe52.abstract
AB How can one cell divide to form two cells, which are genetically identical to the mother cell, with different cell fates? That is the question discussed by Shen and Temple. Specifically, they address how Notch signaling is attenuated in one daughter cell through the asymmetric inheritance of the protein Numb, which may be responsible for mediating the endocytosis of the receptor Notch in the Numb-enriched cell.