PT  - JOURNAL ARTICLE
AU  - Putney, James W.
TI  - Store-Operated Calcium Channels: How Do We Measure Them, and Why Do We Care?
AID  - 10.1126/stke.2432004pe37
DP  - 2004 Jul 27
TA  - Science's STKE
PG  - pe37--pe37
VI  - 2004
IP  - 243
4099  - http://stke.sciencemag.org/content/2004/243/pe37.short
4100  - http://stke.sciencemag.org/content/2004/243/pe37.full
SO  - Sci. STKE2004 Jul 27; 2004
AB  - A major mechanism whereby calcium entry into cells is regulated is the store-operated or capacitative calcium entry pathway. In this article, two basic issues are discussed: (i) the methods investigators use to measure store-operated entry, and (ii) the role played by the store-operated pathway in responses to hormones and neurotransmitters under physiological conditions. The two topics are considered together because they are closely interrelated; as we begin to ask questions about calcium movements at low concentrations of agonists, the technology to measure these movements becomes increasing challenging.