RT Journal Article
SR Electronic
T1 Enhancing Stem Cell Homing
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw296
OP tw296
DO 10.1126/stke.2462004tw296
VO 2004
IS 246
YR 2004
UL http://stke.sciencemag.org/content/2004/246/tw296.abstract
AB The efficiency with which hematopoietic stem cells (HSC) home to the bone marrow is a critical factor determining clinical outcome in transplantation. Christopherson et al. show that efficiency of stem cell homing can be significantly enhanced by interrupting the activity of a peptidase, CD26, on the donor cell surface. Under normal circumstances, CD26 appears to negatively regulate HSC homing by cleavage of the chemokine CXCL12, thereby preventing binding to its receptor on the surface of HSC. The potential ability to increase the efficiency of HSC homing rather than having to isolate greater numbers of the stem cells may help bone marrow transplantation. K. W. Christopherson II, G. Hangoc, C. R. Mantel, H. E. Broxmeyer, Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 305, 1000-1003. [Abstract] [Full Text]