RT Journal Article SR Electronic T1 Focus Issue: Drug Discovery JF Science's STKE JO Sci. STKE FD American Association for the Advancement of Science SP eg7 OP eg7 DO 10.1126/stke.2952005eg7 VO 2005 IS 295 A1 Gough, Nancy R. YR 2005 UL http://stke.sciencemag.org/content/2005/295/eg7.abstract AB This week’s issues of Science and Science’s STKE focus on issues related to the development of therapeutics, including new methods for identifying drug targets and the goal of personalized medicine based on an individual's genetics. STKE specifically looks at the roles the RNAi can play in the drug target identification process, how understanding the genetics behind disease can lead to new options for therapeutic intervention, and how analysis of the signaling network may provide insight for personalized medicine.