PT  - JOURNAL ARTICLE
AU  - Laine, Aaron
AU  - Ronai, Ze′ev
TI  - Ubiquitin Chains in the Ladder of MAPK Signaling
AID  - 10.1126/stke.2812005re5
DP  - 2005 Apr 26
TA  - Science's STKE
PG  - re5--re5
VI  - 2005
IP  - 281
4099  - http://stke.sciencemag.org/content/2005/281/re5.short
4100  - http://stke.sciencemag.org/content/2005/281/re5.full
SO  - Sci. STKE2005 Apr 26; 2005
AB  - With a better understanding of the cellular stress response, it has become evident that catalytic modules consisting of kinases that mediate the activation of downstream effector components are subject to multiple layers of regulation. Such regulatory mechanisms are not limited to those involving scaffold proteins or protein phosphatases, and they appear to include a growing number of modifications by ubiquitin and ubiquitin-like proteins. The role of ubiquitin in the regulation of mitogen-activated protein kinase (MAPK) emerges as a paradigm for understanding the role of ubiquitination in regulating other signal transduction pathways. Ubiquitination influences signal diversification and limits the duration of the signal through its role in the assembly of protein kinase complexes, subcellular localization, and the actual degradation of the kinase or its substrate. This review summarizes our current understanding of the roles of ubiquitin in regulating MAPK signaling.