RT Journal Article
SR Electronic
T1 Agrin Yes, Neuregulin No
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw238
OP tw238
DO 10.1126/stke.2902005tw238
VO 2005
IS 290
YR 2005
UL http://stke.sciencemag.org/content/2005/290/tw238.abstract
AB Neuromuscular junctions develop through a series of reciprocal interactions between the muscle fiber and the incoming motor neuron. Both agrin and neuregulin have been implicated in neuromuscular junction development. Escher et al. use targeted gene ablations to clarify which molecules act when. It seems that neuregulins are not critical for neuromuscular junction formation but agrin is. The previously observed effects of neuregulin signaling disruptions on neuromuscular junction formation may well have been mediated indirectly through the effects of neuregulins on Schwann cells, which surround the neuromuscular junction. P. Escher, E. Lacazette, M. Courtet, A. Blindenbacher, L. Landmann, G. Bezakova, K. C. Lloyd, U. Mueller, H. R. Brenner, Synapses form in skeletal muscles lacking neuregulin receptors. Science 308, 1920-1923 (2005). [Abstract] [Full Text]