PT - JOURNAL ARTICLE AU - McDunn, Jonathan E. AU - Cobb, J. Perren TI - That Which Does Not Kill You Makes You Stronger: A Molecular Mechanism for Preconditioning AID - 10.1126/stke.2912005pe34 DP - 2005 Jul 05 TA - Science's STKE PG - pe34--pe34 VI - 2005 IP - 291 4099 - http://stke.sciencemag.org/content/2005/291/pe34.short 4100 - http://stke.sciencemag.org/content/2005/291/pe34.full SO - Sci. STKE2005 Jul 05; 2005 AB - Preconditioning by sublethal stress can protect a cell from subsequent injury and apoptosis through a mechanism that has been unclear. Many such stresses stimulate the formation of stress granules: transient cytoplasmic foci that contain heat shock protein as well as translationally stalled mRNA and various mRNA-binding proteins. Recent research suggests that sequestration in stress granules of TRAF2, an adaptor protein that is required for tumor necrosis factor receptor 1 signaling, may underlie preconditioning by sublethal stresses.