PT  - JOURNAL ARTICLE
AU  - McDunn, Jonathan E.
AU  - Cobb, J. Perren
TI  - That Which Does Not Kill You Makes You Stronger: A Molecular Mechanism for Preconditioning
AID  - 10.1126/stke.2912005pe34
DP  - 2005 Jul 05
TA  - Science's STKE
PG  - pe34--pe34
VI  - 2005
IP  - 291
4099  - http://stke.sciencemag.org/content/2005/291/pe34.short
4100  - http://stke.sciencemag.org/content/2005/291/pe34.full
SO  - Sci. STKE2005 Jul 05; 2005
AB  - Preconditioning by sublethal stress can protect a cell from subsequent injury and apoptosis through a mechanism that has been unclear. Many such stresses stimulate the formation of stress granules: transient cytoplasmic foci that contain heat shock protein as well as translationally stalled mRNA and various mRNA-binding proteins. Recent research suggests that sequestration in stress granules of TRAF2, an adaptor protein that is required for tumor necrosis factor receptor 1 signaling, may underlie preconditioning by sublethal stresses.