RT Journal Article
SR Electronic
T1 Transduction Peptides Within Naturally Occurring Proteins
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP pe54
OP pe54
DO 10.1126/stke.3132005pe54
VO 2005
IS 313
A1 Joliot, Alain
YR 2005
UL http://stke.sciencemag.org/content/2005/313/pe54.abstract
AB First identified as peptides derived from the human immunodeficiency virus (HIV) transcriptional regulator Tat and the Drosophila transcription factor Antennapedia, transduction (or cell-penetrating) peptide sequences enable soluble proteins to cross biological membranes and interact with cytosolic and nuclear targets. Proteins containing such sequences have been found to function as transcription factors, to inhibit apoptosis, to play roles in axon guidance, or to transport viral mRNA between cells. The recent demonstration that dynorphins are able to act as transduction peptides suggests that these neuropeptides may have roles independent of opiate receptor activation.