PT  - JOURNAL ARTICLE
AU  - Jasny, Barbara R.
TI  - Mapping Biological Connectivity
AID  - 10.1126/stke.3552006tw343
DP  - 2006 Oct 03
TA  - Science's STKE
PG  - tw343--tw343
VI  - 2006
IP  - 355
4099  - http://stke.sciencemag.org/content/2006/355/tw343.short
4100  - http://stke.sciencemag.org/content/2006/355/tw343.full
SO  - Sci. STKE2006 Oct 03; 2006
AB  - Comprehensive catalogs of biological information (such as sequence or protein structure data) can have enormous utility in biomedical research. Lamb et al. have extended this approach to create comprehensive catalogs of cellular states, as defined by RNA expression. The effects of 164 small molecules on the complete messenger RNA expression profiles were examined in established cell lines, with a primary focus on a breast cancer epithelial cell line. By comparing the genomic signature of drug candidates (the anticancer drug gedunin, estrogen, histone deacetylase, and phenothiazine antipyschotics) or a disease state (obesity, Alzheimer’s disease, and dexamethasone-resistant acute lymphoblastic leukemia) to this resource, it was possible to identify potential mechanisms of action, confirm previous applications of known drugs, and identify additional potential uses for known drugs. J. Lamb, E. D. Crawford, D. Peck, J. W. Modell, I. C. Blat, M. J. Wrobel, J. Lerner, J.-P. Brunet, A. Subramanian, K. N. Ross, M. Reich, H. Hieronymus, G. Wei, S. A. Armstrong, S. J. Haggarty, P. A. Clemons, R. Wei, S. A. Carr, E. S. Lander, T. R. Golub, The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935 (2006). [Abstract] [Full Text]