PT  - JOURNAL ARTICLE
AU  - Ray, L. Bryan
TI  - Climbing the Gradient
AID  - 10.1126/stke.3662006tw427
DP  - 2006 Dec 19
TA  - Science's STKE
PG  - tw427--tw427
VI  - 2006
IP  - 366
4099  - http://stke.sciencemag.org/content/2006/366/tw427.short
4100  - http://stke.sciencemag.org/content/2006/366/tw427.full
SO  - Sci. STKE2006 Dec 19; 2006
AB  - During chemotaxis, cells respond to tiny changes in the concentration of chemoattractant molecules and move toward their source. Chen et al. (see the Perspective by Linden) show that in addition to receptors for the chemoattractant peptide N-formyl-Met-Leu-Phe (fMLP), human neutrophils use two other receptor systems to promote appropriate cell migration. Neutrophils exposed to a concentration gradient of fMLP released adenosine triphosphate (ATP) at the leading edge of the cell. The released ATP appeared to act in an autocrine manner and stimulated purinergic receptors to provide a signal required for proper orientation of the cell. Y. Chen, R. Corriden, Y. Inoue, L. Yip, N. Hashiguchi, A. Zinkernagel, V. Nizet, P. A. Insel, W. G. Junger, ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 314, 1792-1795 (2006). [Abstract] [Full Text] J. Linden, Purinergic chemotaxis. Science 314, 1689-1690 (2006). [Abstract] [Full Text]