RT Journal Article
SR Electronic
T1 Beyond Self-Nonself for MHC
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw334
OP tw334
DO 10.1126/stke.3542006tw334
VO 2006
IS 354
A1 Hines, Pamela J.
YR 2006
UL http://stke.sciencemag.org/content/2006/354/tw334.abstract
AB Proteins of the major histocompatibility complex class 1 (MHC1), which are important in identifying self and nonself tissue for the immune system, are also found in the brain. Syken et al. show that a receptor, PirB, to which the MHC1 proteins bind, is also found in neurons of the brain. In mice carrying a mutant PirB lacking its signal transduction capabilities, the overall structure of the brain remained normal. However, these mice showed greater than normal plasticity in the visual cortex. Thus, intercellular signaling through PirB seems to be critical for keeping visual plasticity within limits. J. Syken, T. GrandPre, P. O. Kanold, C. J. Shatz, PirB restricts ocular-dominance plasticity in visual cortex. Science 313, 1795-1800 (2006). [Abstract] [Full Text]