RT Journal Article
SR Electronic
T1 A Foe Motif
JF Science's STKE
JO Sci. STKE
FD American Association for the Advancement of Science
SP tw111
OP tw111
DO 10.1126/stke.3282006tw111
VO 2006
IS 328
YR 2006
UL http://stke.sciencemag.org/content/2006/328/tw111.abstract
AB Pattern recognition receptors, which recognize conserved components found in pathogens but not in the host, are central to the innate immune response. Chang et al. describe the crystal structure at 2.1 angstrom resolution of tracheal cytotoxin (TCT), a fragment of a peptidoglycan specific to Gram-negative bacteria, bound to the ectodomains of the peptidoglycan recognition proteins LCa and LCx. The structure shows how a specificity determinant of Gram-negative bacteria is recognized in the complex and how TCT induces heterodimerization of LCa and LCx to activate downstream signaling. C.-I Chang, Y. Chelliah, D. Borek, D. Mengin-Lecreulx, J. Deisenhofer, Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Science 311, 1761-1764 (2006). [Abstract] [PubMed]