PT  - JOURNAL ARTICLE
ED  - , 
TI  - Revving Up the Circadian Clock
AID  - 10.1126/stke.3232006tw73
DP  - 2006 Feb 21
TA  - Science's STKE
PG  - tw73--tw73
VI  - 2006
IP  - 323
4099  - http://stke.sciencemag.org/content/2006/323/tw73.short
4100  - http://stke.sciencemag.org/content/2006/323/tw73.full
SO  - Sci. STKE2006 Feb 21; 2006
AB  - In mammals, circadian rhythms regulate many aspects of behavior and physiology, including sleep-wake cycles and metabolism. Disruption of these rhythms is associated with certain psychiatric illnesses such as bipolar disorder. Yin et al. describe a potential molecular link between circadian clock control and bipolar disorder. In cultured fibroblasts, a key negative regulator of clock gene expression, the Rev-erbα nuclear receptor, was rapidly degraded after exposure to lithium, which is used in treating bipolar disorder. This destabilization of Rev-erbα led to activation of clock genes. L. Yin, J. Wang, P. S. Klein, M. A. Lazar, Nuclear receptor Rev-erbα is a critical lithium-sensitive component of the circadian clock. Science 311, 1002-1005 (2006). [Abstract] [Full Text]